中華民國獸醫內科醫學會 -
2025-08-06

[202510 台北-內科] 講師介紹 李繼忠 Jihjong J. Lee

李繼忠 Jihjong J. Lee, BVM MS Ph

Associate Professor, Graduate Institute of Veterinary Clinical Sciences School of Veterinary Medicine, National Taiwan University

Specialty

  1. Small Animal Internal Medicine (Oncology)
  2. Medical and Radiation Oncology.
  3. Cancer Immunotherapy and Cell therapy
  4. Clinical Trial

2019, DeFacto diplomate, Asian College of Veterinary Internal Medicine (Oncology)

06/06/11 Ph.D. National Taiwan University

05/19/90 M.S., Louisiana State University.

06/11/83 B.V.M.,  National Taiwan University.

 

Employment Experiences

08/10/18 to Present    Associate Professor, Graduate Institute of Veterinary Clinical Sciences School of Veterinary Medicine, National Taiwan University

 08/01/12 to 07/31/18  Assistant Professor, Graduate Institute of Veterinary Clinical Sciences School of Veterinary Medicine, National Taiwan University

08/01/96 to 07/31/12   Clinical Lecturer, Department of Veterinary Medicine, National Taiwan University.

07/16/90 to 12/31/95   Research associate, College of Veterinary Medicine, North Carolina State University.

08/16/87 to 05/19/90   Graduate assistant, Department of Veterinary Pathology, School of Veterinary Medicine, Louisiana State University

02/01/86 to 06/30/87   Research Assistant, Department of Pathology, College of Medicine, National Taiwan University,

09/01/85 to 12/31/85   Associate veterinarian, Tien-Moo Animal Hospital, Taipei, Taiwan, R.O.C.

Responsibility:

  1. Small animal specialty practice, Medical Oncology, (8 hours/week, oversee 2 resident mentoring, clinical research
  2. Senior veterinary student clinical round (internal medicine/Medical Oncology/Radiation Oncology)
  3. Director, Animal Cancer Treatment Center (2011-present)
  4. Small Animal Medicine Lecture– 12 hrs lecture/Year, respiratory, urinary, hematopoietic, reproductive, and neoplastic diseases
  5. Small Animal Clinical Oncology Lecture– 32 hrs lecture/Year, elective course, lecturing in English
  6. Small Animal Clinical Nutrition Lecture– 32 hrs lecture/Year, basic nutrition and clinical case management, lecturing in English
  7. Radiation Biology and Oncology Lecture – 32 hrs lecture/Year, elective course, Graduate students, cancer radiation related topics, with clinical case discussion
  8. Veterinary Leadership and Management – 32 hrs lecture/Year, 2nd, 3rd, 4th, 5th year students, self motivation, empathy and sympathy, empowering, communication, career planning, fatigue prevention, stress management, interrelationship management
  9. Small Animal Diagnostic Cytology, 32 hrs lecture/year, 5th year students and graduate students, cancer diagnostic cytology with case discussion, 

Research activity:

  1. Cancer novel therapy trial in small animal cancer patients
  2. Multimodality cancer treatments combination and modulation
  3. Microarray screening for novel candidate gene for therapeutic targeting
  4. Clinical trial design and implementation

 

Publications

 

  1. Kuo CC, Yang SY, Liu RM, Lin YH, Liu CC, Huang WH, Lee JJ, Liao AT. Diagnostic Value of Conventional Polymerase Chain Reaction for Detecting BRAF V595E Mutation in Liquid and Tissue Specimens of Canine Urothelial and Prostate Carcinomas. Animals (Basel). 2024 Aug 31;14(17):2535. doi: 10.3390/ani14172535.
  2. Xia YY, Liao AT, Liu RM, Yang SY, Kuo CC, Ke CH, Lin CS, Lee JJ. Immunotherapeutic allogeneic dendritic cell and autologous tumor cell fusion vaccine alone or combined with radiotherapy in canine oral malignant melanoma is safe and potentially effective. Front Vet Sci. 2024 Aug 20;11:1397518. doi: 10.3389/fvets.2024.1397518. eCollection 2024.
  3. Ke CH, Lin CS, Sio KM, Wu CH, Xia YY, Lee JJ, Hu CH, Liu CC, Liaw BS, Cheng CL, Lin KH, Wang YS. DR-70 (fibrinogen-fibrin degradation products) as a prognostic biomarker in dogs with neoplasms, Vet Q. 2024 Dec;44(1):1-10. doi: 10.1080/01652176.2024.2380049. Epub 2024 Jul 19.
  4. Xia Y, Liao AT, Lee J. A retrospective study of chemotherapeutic effect without wide-margin surgery or radiation therapy in dogs with oral malignant melanoma. Can Vet J. 2024 Apr;65(4):343-350. PMID: 38562982 
  5. Xia YY, Chi KH, Liao AT, Lee JJ. Limited Clinical Efficacy with Potential Adverse Events in a Pilot Study of Autologous Adoptive Cell Therapy in Canine Oral Malignant Melanoma. Vet Sci. 2024 Mar 28;11(4):150. doi: 10.3390/vetsci11040150.
  6. Ke CH, Sio KM, Wu CH, Xia YY, Lee JJ, Hu CH, Liu CC, Lu CL, Cheng CL, Lin KH, Tomiyasu H, Wang YS, Lin CS. Increased plasma DR-70 (fibrinogen-fibrin degradation products) concentrations as a diagnostic biomarker in dogs with neoplasms. J Vet Intern Med. 2023 Nov-Dec;37(6):2391-2401. doi: 10.1111/jvim.16898. Epub 2023 Oct 14.PMID: 37837297 
  7. Chen ZF, Hsu YE, Lee JJ, Chou CH. Are They Thinking Differently? The Perceptions and Differences in Medical Disputes between Veterinarians and Clients Vet Sci. 2023 May 22;10(5):367. doi: 10.3390/vetsci10050367.
  8. Chen ZF, Hsu YE, Lee JJ, Chou CH. Perceptions of Veterinarians and Veterinary Students on What Risk Factors Constitute Medical Disputes and Comparisons between 2014 and 2022. Vet Sci. 2023 Mar 6;10(3):200. doi: 10.3390/vetsci10030200.
  9. Zih-Fang Chen 1, Yi-Hsin Elsa Hsu 2 3, Jih-Jong Lee 4, Chung-Hsi Chou 1Bibliometric Analysis of Veterinary Communication Education Research over the Last Two Decades: Rare Yet Essential Vet Sci 2022 May 27;9(6):256. doi: 10.3390/vetsci9060256.
  10. Lee WS, Lee JJ, Liao AT, Kao CL, Wang SL Association between weight change during initial chemotherapy and clinical outcome in dogs with multicentric lymphoma. Vet Comp Oncol. 2021 Mar;19(1):53-60. doi: 10.1111/vco.12637. Epub 2020 Jul 29.
  11. Lee JJ, Liao AT, Wang SL. L-Asparaginase, Doxorubicin, Vincristine, and Prednisolone (LHOP) Chemotherapy as a First-Line Treatment for Dogs with Multicentric Lymphoma. Animals (Basel). 2021 Jul 26;11(8):2199. doi: 10.3390/ani11082199.
  12.  
  13. Kuo IM, Lee JJ, Wang YS, Chiang HC, Huang CC, Hsieh PJ, Han W, Ke CH, Liao ATC, Lin CS. Potential enhancement of host immunity and anti-tumor efficacy of nanoscale curcumin and resveratrol in colorectal cancers by modulated electro- hyperthermia. BMC Cancer. 2020 Jun 29;20(1):603. doi: 10.1186/s12885-020-07072-0.
  15. Lee JJ, Liao AT, Wang SL Outcome of Canine Multicentric Lymphoma after Single or Divided Treatment with Cyclophosphamide in Multidrug Chemotherapy.Top Companion Anim Med. 2020 Nov;41:100461. https://doi:10.1016/j.tcam.2020.10046  Epub 2020 Jun 29.
  16. Chia-Hsin Hsu 1, Hirotaka Tomiyasu 2, Jih-Jong Lee 3, Chun-Wei Tung 4, Chi-Hsun Liao 1, Cheng-Hsun Chuang 5, Ling-Ya Huang 5, Kuang-Wen Liao 5, Chung-Hsi Chou 6, Albert T C Liao 7, Chen-Si Lin 1J Genome-wide DNA methylation analysis using MethylCap-seq in canine high-grade B-cell lymphoma Leukoc Biol. 2021 Jun;109(6):1089-1103. https://doi:10.1002/JLB.2A0820-673R.Epub 2020 Oct 8. `
  17. Jih-Jong Lee, Han-You Lin, Chun-An Chen, Chen-Si Lin, Lih-Chiann Wang,Development of an oligonucleotide microarray for simultaneous detection of two canine MDR1 genotypes and association between genotypes and chemotherapy side effects, Journal of Veterinary Science 2019, 20 (1):27 https://doi.org/10.4142/jvs.2019.20.1.27 
  18. W Chen, I Liu, H Tomiyasu, J Lee, C Cheng, A T Liao, B Liu, C Liu, C Lin, Imatinib Enhances the Anti-Tumor Effect of Doxorubicin in Canine B-cell Lymphoma Cell Line, The Veterinary Journal Volume 254, Dec 2019, http://dx.doi.org/10.1016/j.tvjl.2019.105398 
  19. Kai Chung Cheng, Jih Jong Lee, Shang Lin Wang, Chun Yu Lin, Ching Tien Tseng, Chen Si Lin, Albert Taiching Liao, Elevated plasma YKL-40 level is found in the dogs with cancer and is related to poor prognosis, Journal of Veterinary Science Sep 2019, https://doi.org/10.4142/jvs.2019.20.e53 
  20. Susanne Lin, Chi-Fei Kao, Fun-In Wang, Chian-Ren Jeng, Jih-Jong Lee, Lei-Ya Wang, Hui-Wen Chang, Yi-Jiun Chen, Chen-Hsuan Liu, Victor Pang,Urothelial Carcinomas of the Urinary Bladder With Plasmacytoid or Rhabdoid Features and Tendency of Epithelial-Mesenchymal Transition in 3 Dogs, Veterinary Pathology 55:673-677 April 16, 2018, https://doi.org/10.1177/0300985818771151 
  21. Amily Jou, You-Jin Chen, Ying Li, Ying-Feng Chang, Jih-jong Lee, Albert Liao, Ja-an Ho, Target-Triggered, Dual Amplification Strategy for Sensitive Electrochemical Detection of a Lymphoma-associated MicroRNA,  Electrochimica Acta Vol 236:190-197 2017, http://dx.doi.org/10.1016/j.electacta.2017.03.029
  22. Chung-Hui H Lin, Huey-Dong D Wu, Pei-Ying Y Lo, Jih-Jong J Lee, Chen-Hsuan H Liu Simultaneous visual inspection for barometric whole-body plethysmography waveforms during pulmonary function testing in client-owned cats., Journal of feline medicine and surgery 18(10):761-767 Oct 2016, https://doi.org/10.1177/1098612X15592662
  23. Ya-Wen W Hsiao, Tsung-Ching C Lai, Yu-Hsiang H Lin, Chia-Yi Y Su, Jih-Jong J Lee, Albert T Liao, Yuan-Feng F Lin, Shu-Chen C Hsieh, Alexander T Wu, Michael Hsiao, Granulysin expressed in a humanized mouse model induces apoptotic cell death and suppresses tumorigenicity. Oncotarget 8:83495-83508 Aug 2016, https://doi.org/10.18632/oncotarget.11473 
  24. Yu‐Peng Liu, Jih‐Jong Lee, Tsung‐Ching Lai, Chien‐Hsin Lee, Ya‐Wen Hsiao, Po‐Shen Chen, Wei‐Ting Liu, Chi‐Yuan Hong, Se‐Kwan Lin, Mark‐Yen Kuo, Pei‐Jung Lu, Michael Hsiao Suppressive function of low‐dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha–induced nuclear factor‐kappa B signaling, Head & Neck Apr. 2016
  25. Shang-Lin L Wang, Jih-Jong J Lee, Albert T Liao, Comparison of efficacy and toxicity of doxorubicin and mitoxantrone in combination chemotherapy for canine lymphoma. The Canadian veterinary journal Mar 2016
  26. Chia-Yi Y Su, Yu-Peng P Liu, Chih-Jen J Yang, Yuan-Feng F Lin, Jean Chiou, Li-Hsing H Chi, Jih-Jong J Lee, Alex T Wu, Pei-Jung J Lu, Ming-Shyan S Huang, Michael Hsiao, Plasminogen Activator Inhibitor-2 Plays a Leading Prognostic Role among Protease Families in Non-Small Cell Lung Cancer. PloS one Jul 2015
  27. Chung-Hui Lin, Jih-Jong Lee, Chen-Hsuan Liu, Functional assessment of expiratory flow pattern in feline lower airway disease Journal of Feline Medicine and Surgery 2014
  28. Shang-Lin Wang, Jih-Jong Lee, and Albert Taiching Liao, Case report: Low dose cyclosporine combined ketoconazole cures a dog of sterile nodular panniculitis, Taiwan Veterinary Journal, Vol. 41(1)39-43, 2015
  29. Lee JJ, H. M. Ke, V. F. Pang, and M. Hsiao, Norcantharidine induces apoptosis in osteosarcoma cells through up-regulartion of proapoptotic caspases. Submitted to Biological Biophysical Research Communication
  30. Lee JJ, Chen, PB, Yang, SH, Cheng, CH, Chueh, LL, Pang, VF, Hsiao, M, and Lin, CT. 2007. Effect of the VP3 gene of chicken anemia virus on canine mammary tumor cells. American Journal of Veterinary Research : 68(4):411-22. (SCI)
  31. Kim DY, Cho DY, Lee JJ, Taylor HW. (2003) Malignant peripheral nerve sheath tumor with divergent mesenchymal differentiations in a dog. J Vet Diagn Invest : 15(2):174-8.
  32. Lee CL, Lee JJ, Jeng CR, Wu CH and Yeh LS (2003). Case report: solitary plasmacytoma induced spinal cord compression in a dog. Taiwan Vet. J. 29:311-316.
  33. Lin SK, Kuo MY, Wang JS, Lee JJ, Wang CC, Huang S, Shun CT, Hong CY. (2002) Differential regulation of interleukin-6 and inducible cyclooxygenase gene expression by cytokines through prostaglandin-dependent and -independent mechanisms in human dental pulp fibroblasts. J Endod. 28(3):197-201. (SCI)
  34. Wang FI, Lee JJ, Liu CH, Pang VF, Chang PH, Jeng CR. (2002)  Scirrhous gastric carcinoma with mediastinal invasion in a dog.  J Vet Diagn Invest, 14(1):65-68.  (SCI)
  35. Wu JL, Chen PJ, Lin HK, Lee RS, Lin HL, Liu CJ, Lee PJ, Lee JJ, Chen, DS. (2001) Molecular cloning and expression of woodchuck granulocyte-macrophage colony stimulating factor. J. Medical Virology, 65:567-575. (SCI)
  36. Lin SK, Wang CC, Huang S, Lee JJ, Chiang CP, Lan WH, and Hong CY. (2001). Induction of dental pulp fibroblast matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression by interleukin-1 alpha and tumor necrosis factor-alpha through a prostaglandin-dependent pathway. J. Endodon. 27(3): 185-189. (SCI)
  37. Chiu, CS, Hong CY, Lee JJ, Hsiao M and Chueh LL (2001). Taiwan isolate of chicken anemia virus induces apoptosis in the in vitro culture cells. Journal of the Chinese Society of Veterinary Science27:74-79.
  38. Hong, CY, Huang, SC, Lin, SW, Lee, JJ, Chueh, LL, Lee, CHK, Lin, JH and Hsiao M. (2000). Norcantharidin-induced post-G2/M apoptosis is dependent on wild type p53 gene. Biochemical and Biophysical Research Communications 276:278-285. (SCI)
  39. Hung, KS. Hong, CY. Lee, JJ. Lin, SK. Huang, SC. Wang, TM. Tse, V. Sliverberg, GD. Weng, SC. Hsiao, M. Expression of p16(INK4A) induces dominant suppression of glioblastoma growth in situ through necrosis and cell cycle arrest. Biochemical & Biophysical Research Communications. 269(3):718-25, 2000.
  40. Lee, JJ, Hughes, CS, Fine, RL, Page, RL, P-Glycoprotein Expression In Canine Lymphoma: A Relevant, Intermediate Model of Multidrug Resistance, Cancer, Vol. 77:1892-1898, 1996.
  41. Thrall, DE, Prescott, DM, Samulski, TV, Denman, DL, Legorreta, RL, Rosner, GL, Dodge, RK, Page, RL, Cline, JM, Lee, JJ, Evans, SM, Oleson, JR, and Dewhirst, MW. Radiation and Local Hyperthermia Versus Radiation and Whole body Hyperthermia Combined with Local Hyperthermia in Canine Sarcomas. Int. J. Radiation Oncology Biol. Phys., Vol. 34:1087-1096, 1996.
  42. Page, RL, Lee, JJ, Reviere, JE, Dodge, RK, Thrall, DE, and Dewhirst, MW. Absence of Whole Body Hyperthermia Effect on Cisplatin Distribution in Spontaneous Canine Tumors. Int. J. Radiation Oncology Biol. Phys., Vol. 32:1097-1102, 1995.
  43. Page, RL, Lee, JJ, Reviere, JE, Dodge, RK, Thrall, DE, and Dewhirst, MW. Absence of Whole Body Hyperthermia Effect on Cisplatin Distribution in Spontaneous Canine Tumors. Int. J. Radiation Oncology Biol. Phys., Vol. 32:1097-1102, 1995.
  44. Meyer, RE, Berry, CR, Lee, JJ, Dodge, RK, Page, RL, Thrall, DE. Inspired Anesthetic Gas Humidification Improves Thermal Uniformity During Canine Whole Body Hyperthermia. Int. J. Hyperthermia, Vol. 11:397-407, 1995.
  45. Thrall, DE, Prescott, DM, Samulski, TV, Dewhirst, MW, Cline, JM, Lee, JJ, Page, RL, and Oleson, JR. Serious Toxicity Associated with Annular Microwave Array Induction of Whole Body Hyperthermia in Normal Dogs. Int. J. Hyperthermia, Vol. 8: 23-32, 1992
  46. Master Thesis. “Induction of Metaplastic Respiratory Lesions in Rats: Comparison of Vitamin A Deficiency and n-Nitrosoheptamethylene-imine (NHMI) Administration.”, Louisiana state University, 1990.

 

Poster and Symposium Presentations

 

  1. Wang S. L. and J. J. Lee. 2006. Interpretation and Validation of Fine-needle Aspiration Result in Cutaneous and Subcutaneous Masses. Annual Conference of Taiwan Animal Husbandry and Veterinary Medicine and Chinese Society of Veterinary Science. P. 63, Taipei, December 16
  2. Chueh L. L., S. H. Yang, C. T. Lin and J. J. Lee 2004. Death of canine mammary gland tumor cells induced by VP3 protein of chicken anemia virus. American Society for virology 23th annual meeting. Montreal, Canada.
  3. Chueh LL, Yang SH, Lin CT, and Lee JJ (2004) Death of canine mammary gland tumor cells induced by VP3 protein of chicken anemia virus. American Society for virology 23th annual meeting. Montreal, Canada. Scientific program and abstracts.
  4. Lee, JJ (2001). Updates in Small Animal Oncology, Veterinary Association Malaysia conference, Kuala Lumpur, Malaysia.
  5. Lee JJ, Yeh LS and Liu CH (2000). Canine osteosarcoma. 18th Conference of Chinese Society for Comparative Pathology, P28-32.
  6. Chang, YJ, Lee JJ and Chueh LL and Hsiao M. (2000). Use acquired caspase 3 overexpression as a chemosensitizer in cancer gene therapy. Proceedings of 11th Congress of the Federation of Asian Veterinary Associations. p185
  7. Chu, YY, Lee JJ, Chueh LL and Hsiao M (2000). Osteocalcin promoter-based gene transfer in canine osteosarcoma gene therapy. Proceedings of 11th Congress of the Federation of Asian Veterinary Associations. p184
  8. Case presentation: “Extra skeletal Osteosarcoma in the Spinal Cord and Peripheral Nerve of a Ten-Year-Old Dog.” In: 18th Southeastern Veterinary Pathology Conference, Tifton, Georgia, May 19-20, 1990.
  9. Abstract: “Multidrug Resistance in Canine Lymphoma” In: 15th annual meeting of Veterinary Cancer Society , Townsend, Tennessee, Oct. 22-25, 1994.
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